MAP kinase activation

Bardwell AJ, Frankson E, Bardwell L. Selectivity of Docking Sites in MAPK Kinases. Journal of Biological Chemistry. 2009 May;284(19):13165–73. doi: 10.1074/jbc.m900080200.; Banerjee A, Gerondakis S. Coordinating TLR-activated signaling pathways in cells of the immune system. Immunol Cell Biol. 2007 Aug;85(6):420–4. doi: 10.1038/sj.icb.7100098. PMID: 17637696.; Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response. Annu Rev Immunol. 2002;20():55–72. doi: 10.1146/annurev.immunol.20.091301.131133. PMID: 11861597.; Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001 Mar 01;410(6824):37–40. doi: 10.1038/35065000. PMID: 11242034.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase


Proteins

Protein ID name full name