Nonsense-Mediated Decay (NMD)

Durand S, Lykke-Andersen J. SnapShot: Nonsense-mediated mRNA decay. Cell. 2011 Apr 15;145(2):324–324.e2. doi: 10.1016/j.cell.2011.03.038. PMID: 21496649.; Bhuvanagiri M, Schlitter AM, Hentze MW, Kulozik AE. NMD: RNA biology meets human genetic medicine. Biochem J. 2010 Sep 15;430(3):365–77. doi: 10.1042/bj20100699. PMID: 20795950.; Nicholson P, Yepiskoposyan H, Metze S, Zamudio Orozco R, Kleinschmidt N, Mühlemann O. Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cellular and Molecular Life Sciences. 2009 Oct 27;67(5):677–700. doi: 10.1007/s00018-009-0177-1.; Rebbapragada I, Lykke-Andersen J. Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr Opin Cell Biol. 2009 Jun;21(3):394–402. doi: 10.1016/j.ceb.2009.02.007. PMID: 19359157.; Stalder L, Mühlemann O. The meaning of nonsense. Trends Cell Biol. 2008 Jul;18(7):315–21. doi: 10.1016/j.tcb.2008.04.005. PMID: 18524595.; Neu-Yilik G, Kulozik AE. NMD: multitasking between mRNA surveillance and modulation of gene expression. Adv Genet. 2008;62():185–243. doi: 10.1016/s0065-2660(08)00604-4. PMID: 19010255.; Isken O, Maquat LE. Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev. 2007 Aug 01;21(15):1833–56. doi: 10.1101/gad.1566807. PMID: 17671086.; Chang YF, Imam JS, Wilkinson MF. The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem. 2007;76():51–74. doi: 10.1146/annurev.biochem.76.050106.093909. PMID: 17352659.; Behm-Ansmant I, Kashima I, Rehwinkel J, Saulière J, Wittkopp N, Izaurralde E. mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett. 2007 Jun 19;581(15):2845–53. doi: 10.1016/j.febslet.2007.05.027. PMID: 17531985.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.6.4.12 DNA helicase
3.6.4.13 RNA helicase


Proteins

Protein ID name full name