RAF-independent MAPK1/3 activation

Kuriakose T, Rada B, Watford WT. Tumor Progression Locus 2-dependent Oxidative Burst Drives Phosphorylation of Extracellular Signal-regulated Kinase during TLR3 and 9 Signaling. Journal of Biological Chemistry. 2014 Dec;289(52):36089–100. doi: 10.1074/jbc.m114.587121.; Arthur JS, Ley SC. Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol. 2013 Sep;13(9):679–92. doi: 10.1038/nri3495. PMID: 23954936.; Roskoski R. ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol Res. 2012 Aug;66(2):105–43. doi: 10.1016/j.phrs.2012.04.005. PMID: 22569528.; Kyriakis JM, Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev. 2012 Apr;92(2):689–737. doi: 10.1152/physrev.00028.2011. PMID: 22535895.; Gantke T, Sriskantharajah S, Ley SC. Regulation and function of TPL-2, an I?B kinase-regulated MAP kinase kinase kinase. Cell Res. 2011 Jan;21(1):131–45. PMID: 21135874; PMCID: PMC3193413.; Wang J, Whiteman MW, Lian H, Wang G, Singh A, Huang D, Denmark T. A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1. Journal of Biological Chemistry. 2009 Aug;284(32):21412–24. doi: 10.1074/jbc.m109.026013.; Dawson CW, Laverick L, Morris MA, Tramoutanis G, Young LS. Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. J Virol. 2008 Apr;82(7):3654–64. PMID: 18199641; PMCID: PMC2268486.; Shaul YD, Seger R. The MEK/ERK cascade: From signaling specificity to diverse functions. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2007 Aug;1773(8):1213–26. doi: 10.1016/j.bbamcr.2006.10.005.; Hsu MC, Chang HC, Hung WC. HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. J Biol Chem. 2006 Feb 24;281(8):4718–25. doi: 10.1074/jbc.m510937200. PMID: 16377629.; Yoon S, Seger R. The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors. 2006 Mar;24(1):21–44. doi: 10.1080/02699050500284218. PMID: 16393692.; VIAL E, POUYSSÉGUR J. Regulation of Tumor Cell Motility by ERK Mitogen-Activated Protein Kinases. Annals of the New York Academy of Sciences. 2004 Dec;1030(1):208–18. doi: 10.1196/annals.1329.027.; Zuber J, Tchernitsa OI, Hinzmann B, Schmitz AC, Grips M, Hellriegel M, Sers C, Rosenthal A, Schäfer R. A genome-wide survey of RAS transformation targets. Nat Genet. 2000 Feb;24(2):144–52. doi: 10.1038/72799. PMID: 10655059.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase


Proteins

Protein ID name full name