MyD88:MAL(TIRAP) cascade initiated on plasma membrane

Gangloff M, Gay NJ. MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci. 2004 Jun;29(6):294–300. doi: 10.1016/j.tibs.2004.04.008. PMID: 15276183.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.-.-
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.10 IkappaB kinase ATP:[IkappaB protein] phosphotransferase
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)


Proteins

Protein ID name full name