Signaling by EGFR

Dzul Keflee R, Leong KH, Ogawa S, Bignon J, Chan MC, Kong KW. Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer. Biochem Pharmacol. 2022 Nov;205():115262. doi: 10.1016/j.bcp.2022.115262. PMID: 36191627.; Uribe ML, Marrocco I, Yarden Y. EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance. Cancers (Basel). 2021 Jun 01;13(11). PMID: 34206026; PMCID: PMC8197917.; Bartel CA, Parameswaran N, Cipriano R, Jackson MW. FAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistance. Oncotarget. 2016 Aug 09;7(32):52597–612. PMID: 27221039; PMCID: PMC5239576.; Avraham R, Yarden Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nature Reviews Molecular Cell Biology. 2011 Jan 21;12(2):104–17. doi: 10.1038/nrm3048.; Herbst RS. Review of epidermal growth factor receptor biology. International Journal of Radiation Oncology*Biology*Physics. 2004 Jun;59(2):S21–6. doi: 10.1016/j.ijrobp.2003.11.041.; Schlessinger J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell. 2002 Sep 20;110(6):669–72. doi: 10.1016/s0092-8674(02)00966-2. PMID: 12297041.; Carpenter G. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways. J Cell Biol. 1999 Aug 23;146(4):697–702. PMID: 10459005; PMCID: PMC2156131.; Wells A. EGF receptor. The International Journal of Biochemistry & Cell Biology. 1999 Jun;31(6):637–43. doi: 10.1016/s1357-2725(99)00015-1.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.137 phosphatidylinositol 3-kinase ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
2.7.10.1 receptor protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.1.4.11 phosphoinositide phospholipase C 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name