Formation of Incision Complex in GG-NER

King BS, Cooper KL, Liu KJ, Hudson LG. Poly(ADP-ribose) Contributes to an Association between Poly(ADP-ribose) Polymerase-1 and Xeroderma Pigmentosum Complementation Group A in Nucleotide Excision Repair. Journal of Biological Chemistry. 2012 Nov;287(47):39824–33. doi: 10.1074/jbc.m112.393504.; Orelli B, McClendon TB, Tsodikov OV, Ellenberger T, Niedernhofer LJ, Schärer OD. The XPA-binding domain of ERCC1 Is Required for Nucleotide Excision Repair but Not Other DNA Repair Pathways. Journal of Biological Chemistry. 2010 Feb;285(6):3705–12. doi: 10.1074/jbc.m109.067538.; Tsodikov OV, Ivanov D, Orelli B, Staresincic L, Shoshani I, Oberman R, Schärer OD, Wagner G, Ellenberger T. Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA. EMBO J. 2007 Nov 14;26(22):4768–76. PMID: 17948053; PMCID: PMC2080803.; Coin F, Oksenych V, Egly JM. Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol Cell. 2007 Apr 27;26(2):245–56. doi: 10.1016/j.molcel.2007.03.009. PMID: 17466626.; Zotter A, Luijsterburg MS, Warmerdam DO, Ibrahim S, Nigg A, van Cappellen WA, Hoeijmakers JHJ, van Driel R, Vermeulen W, Houtsmuller AB. Recruitment of the Nucleotide Excision Repair Endonuclease XPG to Sites of UV-Induced DNA Damage Depends on Functional TFIIH. Molecular and Cellular Biology. 2006 Dec 01;26(23):8868–79. doi: 10.1128/mcb.00695-06.; Camenisch U, Dip R, Schumacher SB, Schuler B, Naegeli H. Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair. Nature Structural & Molecular Biology. 2006 Feb 19;13(3):278–84. doi: 10.1038/nsmb1061.; Dunand-Sauthier I, Hohl M, Thorel F, Jaquier-Gubler P, Clarkson SG, Schärer OD. The Spacer Region of XPG Mediates Recruitment to Nucleotide Excision Repair Complexes and Determines Substrate Specificity. Journal of Biological Chemistry. 2005 Feb;280(8):7030–7. doi: 10.1074/jbc.m412228200.; Riedl T, Hanaoka F, Egly JM. The comings and goings of nucleotide excision repair factors on damaged DNA. EMBO J. 2003 Oct 01;22(19):5293–303. PMID: 14517266; PMCID: PMC204472.; Volker M, Moné MJ, Karmakar P, van Hoffen A, Schul W, Vermeulen W, Hoeijmakers JH, van Driel R, van Zeeland AA, Mullenders LH. Sequential assembly of the nucleotide excision repair factors in vivo. Mol Cell. 2001 Jul;8(1):213–24. doi: 10.1016/s1097-2765(01)00281-7. PMID: 11511374.; de Laat WL, Appeldoorn E, Sugasawa K, Weterings E, Jaspers NG, Hoeijmakers JH. DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair. Genes Dev. 1998 Aug 15;12(16):2598–609. PMID: 9716411; PMCID: PMC317078.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
5.6.2.3 DNA 5'-3' helicase DNA 5'-3' helicase (ATP-hydrolysing)
5.6.2.4 DNA 3'-5' helicase DNA 3'-5' helicase (ATP-hydrolysing)


Proteins

Protein ID name full name