ester phospholipid biosynthesis

Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM. Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. EMBO J. 2007 Feb 21;26(4):1094–104. PMID: 17290222; PMCID: PMC1852826.; Zufferey R, Mamoun CB. The initial step of glycerolipid metabolism in Leishmania major promastigotes involves a single glycerol-3-phosphate acyltransferase enzyme important for the synthesis of triacylglycerol but not essential for virulence. Molecular Microbiology. 2005 Mar 15;56(3):800–10. doi: 10.1111/j.1365-2958.2005.04579.x.; Zufferey R, Mamoun CB. Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs. Molecular and Biochemical Parasitology. 2002 Nov;125(1-2):127–34. doi: 10.1016/s0166-6851(02)00220-7.; Wassef MK, Fioretti TB, Dwyer DM. Lipid analyses of isolated surface membranes of Leishmania donovani promastigotes. Lipids. 1985 Feb;20(2):108–15. doi: 10.1007/bf02534216. PMID: 3982233.

Metabolites

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

CDP-choline

Formula: C14H26N4O11P2 (488.10732659999996)

CAS ID: 987-78-0

CDP-ethanolamine

Formula: C11H20N4O11P2 (446.06037899999995)

CAS ID: 3036-18-8

Choline

Formula: C5H14NO (104.10753340000001)

CAS ID: 62-49-7

Choline phosphate

Formula: C5H15NO4P (184.07386599999998)

CAS ID: 107-73-3

CMP

Formula: C9H14N3O8P (323.05184940000004)

CAS ID: 63-37-6

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Ethanolamine

Formula: C2H7NO (61.0527612)

CAS ID: 141-43-5

Ethanolamine phosphate

Formula: C2H8NO4P (141.0190938)

CAS ID: 1071-23-4

Glycerol

Formula: C3H8O3 (92.0473418)

CAS ID: 56-81-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

myo-Inositol

Formula: C6H12O6 (180.0633852)

CAS ID: 87-89-8

Orthophosphate

Formula: H3PO4 (97.9768968)

CAS ID: 7664-38-2

S-Adenosyl-L-methionine

Formula: C15H22N6O5S (398.1372322)

CAS ID: 29908-03-0

sn-Glycerol 3-phosphate

Formula: C3H9O6P (172.01367439999999)

CAS ID: 17989-41-2



Enzyme

EC Number name full name note


Proteins

Protein ID name full name