G alpha (i) signalling events

Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457–62. PMID: 18434541; PMCID: PMC2359823.; Dessauer CW, Chen-Goodspeed M, Chen J. Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase. J Biol Chem. 2002 Aug 09;277(32):28823–9. doi: 10.1074/jbc.m203962200. PMID: 12058044.; Ma YC, Huang J, Ali S, Lowry W, Huang XY. Src tyrosine kinase is a novel direct effector of G proteins. Cell. 2000 Sep 01;102(5):635–46. doi: 10.1016/s0092-8674(00)00086-6. PMID: 11007482.; Hildebrandt JD. Role of subunit diversity in signaling by heterotrimeric G proteins. Biochem Pharmacol. 1997 Aug 01;54(3):325–39. doi: 10.1016/s0006-2952(97)00269-4. PMID: 9278091.; Gilman AG. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987;56():615–49. doi: 10.1146/annurev.bi.56.070187.003151. PMID: 3113327.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4



Enzyme

EC Number name full name note
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase


Proteins

Protein ID name full name