L-phenylalanine biosynthesis II

Cho MH, Corea OR, Yang H, Bedgar DL, Laskar DD, Anterola AM, Moog-Anterola FA, Hood RL, Kohalmi SE, Bernards MA, Kang C, Davin LB, Lewis NG. Phenylalanine biosynthesis in Arabidopsis thaliana. Identification and characterization of arogenate dehydratases. J Biol Chem. 2007 Oct 19;282(42):30827–35. doi: 10.1074/jbc.m702662200. PMID: 17726025.; Warpeha KM, Lateef SS, Lapik Y, Anderson M, Lee BS, Kaufman LS. G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis. Plant Physiol. 2006 Mar;140(3):844–55. PMID: 16415218; PMCID: PMC1400578.; Siehl DL, Conn EE. Kinetic and regulatory properties of arogenate dehydratase in seedlings of Sorghum bicolor (L.) moench. Archives of Biochemistry and Biophysics. 1988 Feb;260(2):822–9. doi: 10.1016/0003-9861(88)90513-9.; Jung E, Zamir LO, Jensen RA. Chloroplasts of higher plants synthesize L-phenylalanine via L-arogenate. Proc. Natl. Acad. Sci. U.S.A. 1986 Oct;83(19):7231–5. doi: 10.1073/pnas.83.19.7231.; Bonner CA, Jensen RA. Novel features of prephenate aminotransferase from cell cultures of Nicotiana silvestris. Archives of Biochemistry and Biophysics. 1985 Apr;238(1):237–46. doi: 10.1016/0003-9861(85)90161-4.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3



Enzyme

EC Number name full name note
2.6.1.1 aspartate transaminase L-aspartate:2-oxoglutarate aminotransferase
2.6.1.78 aspartate-prephenate aminotransferase L-arogenate:oxaloacetate aminotransferase
2.6.1.79 glutamate-prephenate aminotransferase L-arogenate:2-oxoglutarate aminotransferase
4.2.1.51 prephenate dehydratase prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)
4.2.1.91 arogenate dehydratase L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)
5.4.99.5 chorismate mutase Chorismate pyruvatemutase


Proteins

Protein ID name full name