DNA Double-Strand Break Repair

Ciccia A, Elledge SJ. The DNA Damage Response: Making It Safe to Play with Knives. Molecular Cell. 2010 Oct;40(2):179–204. doi: 10.1016/j.molcel.2010.09.019.; Rothkamm K, Krüger I, Thompson LH, Lübrich M. Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle. Molecular and Cellular Biology. 2003 Aug 01;23(16):5706–15. doi: 10.1128/mcb.23.16.5706-5715.2003.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.-.-
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.1.21.10 crossover junction endodeoxyribonuclease


Proteins

Protein ID name full name
P39750 rad2 Flap endonuclease 1
P87231 mus81 Crossover junction endonuclease mus81
Q09683 rad32 Double-strand break repair protein rad32
Q10292 mek1 Meiosis-specific serine/threonine-protein kinase mek1
Q9C103 eme1 Crossover junction endonuclease eme1
Q9UTJ8 rad50 DNA repair protein rad50