Transcriptional Regulation by TP53

Kruiswijk F, Labuschagne CF, Vousden KH. p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nature Reviews Molecular Cell Biology. 2015 Jun 23;16(7):393–405. doi: 10.1038/nrm4007.; Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell. 2009 May 01;137(3):413–31. doi: 10.1016/j.cell.2009.04.037. PMID: 19410540.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

6-O-phosphonato-D-glucono-1,5-lactone(2-)

Formula: C6H9O9P (255.99841940000002)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
5.1.3.-
1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+) D-glucose-6-phosphate:NADP+ 1-oxidoreductase
1.11.1.24 thioredoxin-dependent peroxiredoxin thioredoxin:hydroperoxide oxidoreductase
1.8.1.7 glutathione-disulfide reductase glutathione:NADP+ oxidoreductase
2.5.1.60 protein geranylgeranyltransferase type II geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
4.6.1.1 adenylate cyclase ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase
5.3.1.9 glucose-6-phosphate isomerase alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)
5.6.2.3 DNA 5'-3' helicase DNA 5'-3' helicase (ATP-hydrolysing)
5.6.2.4 DNA 3'-5' helicase DNA 3'-5' helicase (ATP-hydrolysing)


Proteins

Protein ID name full name
O00091 zwf1 Glucose-6-phosphate 1-dehydrogenase
O13768 ptr8 General transcription and DNA repair factor IIH helicase/translocase subunit XPB
O13853 its3 Phosphatidylinositol 4-phosphate 5-kinase its3
O14098 lsk1 CTD kinase subunit alpha
O74448 pin1 Peptidyl-prolyl cis-trans isomerase pin1
O74887 tpx1 Peroxiredoxin tpx1
O94412 bet4 Geranylgeranyl transferase type-2 subunit alpha
P06652 cdc25 M-phase inducer phosphatase
P14605 cyr1 Adenylate cyclase
P26659 rad15 General transcription and DNA repair factor IIH helicase subunit XPD
P46960 ptb1 Geranylgeranyl transferase type-2 subunit beta
P50528 plo1 Serine/threonine-protein kinase plo1
P78917 pgi1 Glucose-6-phosphate isomerase
P78965 pgr1 Glutathione reductase
Q12701 ksg1 Serine/threonine-protein kinase ksg1
Q9P376 fcp1 RNA polymerase II subunit A C-terminal domain phosphatase
Q9Y7K2 tor2 Serine/threonine-protein kinase tor2