Toll Like Receptor 10 (TLR10) Cascade

Nyman T, Stenmark P, Flodin S, Johansson I, Hammarström M, Nordlund P. The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer. Journal of Biological Chemistry. 2008 May;283(18):11861–5. doi: 10.1074/jbc.c800001200.; Hasan U, Chaffois C, Gaillard C, Saulnier V, Merck E, Tancredi S, Guiet C, Brière F, Vlach J, Lebecque S, Trinchieri G, Bates EE. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol. 2005 Mar 01;174(5):2942–50. doi: 10.4049/jimmunol.174.5.2942. PMID: 15728506.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase


Proteins

Protein ID name full name
O13453 pmp1 Tyrosine-protein phosphatase pmp1
Q09892 sty1 Mitogen-activated protein kinase sty1
Q12706 psk1 Serine/threonine-protein kinase psk1
Q92398 spm1 Mitogen-activated protein kinase spm1