Intracellular signaling by second messengers

Levine TP, Patel S. Signalling at membrane contact sites: two membranes come together to handle second messengers. Curr Opin Cell Biol. 2016 Apr;39():77–83. doi: 10.1016/j.ceb.2016.02.011. PMID: 26922871.; Raker VK, Becker C, Steinbrink K. The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases. Front. Immunol. 2016 Mar 31;7(). doi: 10.3389/fimmu.2016.00123.; Kang D, Yang YR, Lee C, Kim S, Ryu SH, Suh P. Roles of phosphoinositide-specific phospholipase C?1 in brain development. Advances in Biological Regulation. 2016 Jan;60():167–73. doi: 10.1016/j.jbior.2015.10.002.; Pinto MC, Kihara AH, Goulart VA, Tonelli FM, Gomes KN, Ulrich H, Resende RR. Calcium signaling and cell proliferation. Cell Signal. 2015 Nov;27(11):2139–49. doi: 10.1016/j.cellsig.2015.08.006. PMID: 26275497.; Ahmad F, Murata T, Shimizu K, Degerman E, Maurice D, Manganiello V. Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets. Oral Dis. 2015 Jan;21(1):e25–50. PMID: 25056711; PMCID: PMC4275405.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4



Enzyme

EC Number name full name note
2.7.1.67 1-phosphatidylinositol 4-kinase ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase
2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase


Proteins

Protein ID name full name
P24583 PKC1 Protein kinase C-like 1
P32600 TOR2 Serine/threonine-protein kinase TOR2
P38070 YPK3 Serine/threonine-protein kinase YPK3
P38994 MSS4 Phosphatidylinositol 4-phosphate 5-kinase MSS4
P53916 TEP1 Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1
Q12236 PKH2 Serine/threonine-protein kinase PKH2