FCERI mediated MAPK activation

Alvarez-Errico D, Lessmann E, Rivera J. Adapters in the organization of mast cell signaling. Immunological Reviews. 2009 Oct 23;232(1):195–217. doi: 10.1111/j.1600-065x.2009.00834.x.; Gilfillan AM, Rivera J. The tyrosine kinase network regulating mast cell activation. Immunological Reviews. 2009 Mar;228(1):149–69. doi: 10.1111/j.1600-065x.2008.00742.x.; Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T. LAT and NTAL Mediate Immunoglobulin E-Induced Sustained Extracellular Signal-Regulated Kinase Activation Critical for Mast Cell Survival. Molecular and Cellular Biology. 2007 Jun 01;27(12):4406–15. doi: 10.1128/mcb.02109-06.; Kopec A, Panaszek B, Fal AM. Intracellular signaling pathways in IgE-dependent mast cell activation. Archivum Immunologiae et Therapiae Experimentalis. 2006 Nov 21;54(6):393–401. doi: 10.1007/s00005-006-0049-4.; Gilfillan AM, Tkaczyk C. Integrated signalling pathways for mast-cell activation. Nat Rev Immunol. 2006 Mar;6(3):218–30. doi: 10.1038/nri1782. PMID: 16470226.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name