VEGFA-VEGFR2 Pathway

Claesson-Welsh L, Welsh M. VEGFA and tumour angiogenesis. J Intern Med. 2013 Feb;273(2):114–27. doi: 10.1111/joim.12019. PMID: 23216836.; Lohela M, Bry M, Tammela T, Alitalo K. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol. 2009 Apr;21(2):154–65. doi: 10.1016/j.ceb.2008.12.012. PMID: 19230644.; Otrock ZK, Makarem JA, Shamseddine AI. Vascular endothelial growth factor family of ligands and receptors: Review. Blood Cells, Molecules, and Diseases. 2007 May;38(3):258–68. doi: 10.1016/j.bcmd.2006.12.003.; Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 2006 May;7(5):359–71. doi: 10.1038/nrm1911. PMID: 16633338.; Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res. 2006 Mar 10;312(5):549–60. doi: 10.1016/j.yexcr.2005.11.012. PMID: 16336962.; Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L. VEGF-receptor signal transduction. Trends Biochem Sci. 2003 Sep;28(9):488–94. doi: 10.1016/s0968-0004(03)00193-2. PMID: 13678960.; Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995 Jul 06;376(6535):62–6. doi: 10.1038/376062a0. PMID: 7596435.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Nitric oxide

Formula: NO (29.997989)

CAS ID: 10102-43-9

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Superoxide

Formula: O2 (31.98983)

CAS ID: 11062-77-4

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

L-argininium(1+)

Formula: C6H15N4O2 (175.119495)

CAS ID: 17806-42-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.3.1.-
1.14.13.39 nitric-oxide synthase (NADPH) L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
2.7.1.91 sphingosine kinase ATP:sphingoid base 1-phosphotransferase
2.7.10.1 receptor protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.1.4.11 phosphoinositide phospholipase C 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name