ADP signalling through P2Y purinoceptor 1

Gachet C, Léon C, Hechler B. The platelet P2 receptors in arterial thrombosis. Blood Cells, Molecules, and Diseases. 2006 Mar;36(2):223–7. doi: 10.1016/j.bcmd.2005.12.024.; Woulfe D, Yang J, Brass L. ADP and platelets: the end of the beginning. J Clin Invest. 2001 Jun;107(12):1503–5. PMID: 11413156; PMCID: PMC200202.; Jin J, Daniel JL, Kunapuli SP. Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J Biol Chem. 1998 Jan 23;273(4):2030–4. doi: 10.1074/jbc.273.4.2030. PMID: 9442040.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase


Proteins

Protein ID name full name