Metabolism of nitric oxide: NOS3 activation and regulation

Pacher P, Beckman JS, Liaudet L. Nitric Oxide and Peroxynitrite in Health and Disease. Physiological Reviews. 2007 Jan;87(1):315–424. doi: 10.1152/physrev.00029.2006.; Oess S, Icking A, Fulton D, Govers R, Müller-Esterl W. Subcellular targeting and trafficking of nitric oxide synthases. Biochem J. 2006 Jun 15;396(3):401–9. PMID: 16722822; PMCID: PMC1482820.; Kone BC, Kuncewicz T, Zhang W, Yu Z. Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. American Journal of Physiology-Renal Physiology. 2003 Aug;285(2):F178–90. doi: 10.1152/ajprenal.00048.2003.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nitric oxide

Formula: NO (29.997989)

CAS ID: 10102-43-9

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Superoxide

Formula: O2 (31.98983)

CAS ID: 11062-77-4

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Nitrate

Formula: NO3 (61.987819)

CAS ID: 14797-55-8

L-argininium(1+)

Formula: C6H15N4O2 (175.119495)

CAS ID: 17806-42-7

hexadecanoate

Formula: C16H31O2 (255.2323926)

CAS ID: 143-20-4

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.11.1.-
1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) L-erythro-7,8-dihydrobiopterin:NADP+ oxidoreductase
1.14.13.39 nitric-oxide synthase (NADPH) L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
1.15.1.1 superoxide dismutase superoxide:superoxide oxidoreductase
2.3.1.225 protein S-acyltransferase palmitoyl-CoA:[protein]-L-cysteine S-palmitoyltransferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.1.2.22 palmitoyl[protein] hydrolase palmitoyl[protein] hydrolase
3.5.3.18 dimethylargininase Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.5.5 dynamin GTPase GTP phosphohydrolase (vesicle-releasing)


Proteins

Protein ID name full name