DDX58/IFIH1-mediated induction of interferon-alpha/beta

Son KN, Liang Z, Lipton HL. Double-Stranded RNA Is Detected by Immunofluorescence Analysis in RNA and DNA Virus Infections, Including Those by Negative-Stranded RNA Viruses. J Virol. 2015 Sep;89(18):9383–92. PMID: 26136565; PMCID: PMC4542381.; Bowie AG, Unterholzner L. Viral evasion and subversion of pattern-recognition receptor signalling. Nat Rev Immunol. 2008 Dec;8(12):911–22. PMID: 18989317; PMCID: PMC7097711.; Yoneyama M, Fujita T. Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity. 2008 Aug 15;29(2):178–81. doi: 10.1016/j.immuni.2008.07.009. PMID: 18701081.; Loo YM, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez-Sobrido L, Akira S, Gill MA, García-Sastre A, Katze MG, Gale M. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol. 2008 Jan;82(1):335–45. PMID: 17942531; PMCID: PMC2224404.; Yoneyama M, Fujita T. RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity. Cytokine Growth Factor Rev. 2007 Oct;18(5-6):545–51. doi: 10.1016/j.cytogfr.2007.06.023. PMID: 17683970.; Yoneyama M, Fujita T. Function of RIG-I-like Receptors in Antiviral Innate Immunity. Journal of Biological Chemistry. 2007 May;282(21):15315–8. doi: 10.1074/jbc.r700007200.; Weber F, Wagner V, Rasmussen SB, Hartmann R, Paludan SR. Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses. J Virol. 2006 May 15;80(10):5059–64. doi: 10.1128/jvi.80.10.5059-5064.2006.; Honda K, Yanai H, Takaoka A, Taniguchi T. Regulation of the type I IFN induction: a current view. Int Immunol. 2005 Nov;17(11):1367–78. doi: 10.1093/intimm/dxh318. PMID: 16214811.; Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol. 2004 Jul;5(7):730–7. doi: 10.1038/ni1087. PMID: 15208624.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.-
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.10 IkappaB kinase ATP:[IkappaB protein] phosphotransferase
3.4.19.12 ubiquitinyl hydrolase 1
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.4.13 RNA helicase
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase


Proteins

Protein ID name full name