Class I MHC mediated antigen processing & presentation

Wearsch PA, Cresswell P. The quality control of MHC class I peptide loading. Current Opinion in Cell Biology. 2008 Dec;20(6):624–31. doi: 10.1016/j.ceb.2008.09.005.; Vyas JM, Van der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation. Nat Rev Immunol. 2008 Aug;8(8):607–18. PMID: 18641646; PMCID: PMC2735460.; Purcell AW, Elliott T. Molecular machinations of the MHC-I peptide loading complex. Curr Opin Immunol. 2008 Feb;20(1):75–81. doi: 10.1016/j.coi.2007.12.005. PMID: 18243674.; Elliott T, Neefjes J. The complex route to MHC class I-peptide complexes. Cell. 2006 Oct 20;127(2):249–51. doi: 10.1016/j.cell.2006.10.001. PMID: 17055423.; Loureiro J, Ploegh HL. Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Adv Immunol. 2006;92():225–305. PMID: 17145306; PMCID: PMC7112114.; Antoniou AN, Powis SJ, Elliott T. Assembly and export of MHC class I peptide ligands. Curr Opin Immunol. 2003 Feb;15(1):75–81. doi: 10.1016/s0952-7915(02)00010-9. PMID: 12495737.; York IA, Rock KL. Antigen processing and presentation by the class I major histocompatibility complex. Annu Rev Immunol. 1996;14():369–96. doi: 10.1146/annurev.immunol.14.1.369. PMID: 8717519.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

NADPH

Formula: C21H30N7O17P3 (745.0911)

CAS ID: 2646-71-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Superoxide

Formula: O2 (31.98983)

CAS ID: 11062-77-4

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.6.3.-
3.4.11.3 cystinyl aminopeptidase
3.4.24.15 thimet oligopeptidase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)
5.3.4.1 protein disulfide-isomerase Protein disulfide-isomerase
7.4.2.14 ABC-type antigen peptide transporter ATP phosphohydrolase (ABC-type, antigen peptide-exporting)


Proteins

Protein ID name full name