Regulation of mRNA stability by proteins that bind AU-rich elements

Barreau C, Paillard L, Osborne HB. AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res. 2005;33(22):7138–50. PMID: 16391004; PMCID: PMC1325018.; Gingerich TJ, Feige JJ, LaMarre J. AU-rich elements and the control of gene expression through regulated mRNA stability. Anim Health Res Rev. 2004 Jun;5(1):49–63. doi: 10.1079/ahr200460. PMID: 15460540.; Bevilacqua A, Ceriani MC, Capaccioli S, Nicolin A. Post-transcriptional regulation of gene expression by degradation of messenger RNAs. Journal Cellular Physiology. 2003 Mar 31;195(3):356–72. doi: 10.1002/jcp.10272.; Zhang T, Kruys V, Huez G, Gueydan C. AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors. Biochem Soc Trans. 2002 Nov;30(Pt 6):952–8. doi: 10.1042/bst0300952. PMID: 12440953.

Metabolites

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.13.-
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
3.1.13.4 poly(A)-specific ribonuclease
3.6.1.62 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] N7-methylguanosine-5'-diphosphate phosphohydrolase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)


Proteins

Protein ID name full name