Interferon alpha/beta signaling

Uzé G, Schreiber G, Piehler J, Pellegrini S. The receptor of the type I interferon family. Curr Top Microbiol Immunol. 2007;316():71–95. doi: 10.1007/978-3-540-71329-6_5. PMID: 17969444.; Gauzzi MC, Velazquez L, McKendry R, Mogensen KE, Fellous M, Pellegrini S. Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J Biol Chem. 1996 Aug 23;271(34):20494–500. doi: 10.1074/jbc.271.34.20494. PMID: 8702790.; Li X, Leung S, Qureshi S, Darnell JE, Stark GR. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J Biol Chem. 1996 Mar 08;271(10):5790–4. doi: 10.1074/jbc.271.10.5790. PMID: 8621447.; Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ. Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. The EMBO Journal. 1996 Mar;15(5):1064–74. doi: 10.1002/j.1460-2075.1996.tb00444.x.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.4.-
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.1.13.1 exoribonuclease II
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.4.19.12 ubiquitinyl hydrolase 1
3.4.25.1 proteasome endopeptidase complex
3.5.4.37 double-stranded RNA adenine deaminase double-stranded RNA(adenine) aminohydrolase


Proteins

Protein ID name full name