TICAM1-dependent activation of IRF3/IRF7
Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P. Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon ß. Biochem J. 2017 Mar 15;474(7):1163–74. PMID: 28159912; PMCID: PMC5350611.; Tenoever BR, Ng SL, Chua MA, McWhirter SM, García-Sastre A, Maniatis T. Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science. 2007 Mar 02;315(5816):1274–8. doi: 10.1126/science.1136567. PMID: 17332413.; Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nature Structural & Molecular Biology. 2004 Oct 24;11(11):1060–7. doi: 10.1038/nsmb847.; Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S. The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med. 2004 Jun 21;199(12):1641–50. PMID: 15210742; PMCID: PMC2212809.; McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 2003 Dec 16;101(1):233–8. doi: 10.1073/pnas.2237236100.; Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003 Aug 01;301(5633):640–3. doi: 10.1126/science.1087262. PMID: 12855817.