Regulation of MECP2 expression and activity

Su M, Hong J, Zhao Y, Liu S, Xue X. MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA-132 in rats with depression. Mol Med Rep. 2015 Oct;12(4):5399–406. doi: 10.3892/mmr.2015.4104. PMID: 26239616.; Li H, Zhong X, Chau KF, Santistevan NJ, Guo W, Kong G, Li X, Kadakia M, Masliah J, Chi J, Jin P, Zhang J, Zhao X, Chang Q. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nature Communications. 2014 Nov 25;5(1):5601. doi: 10.1038/ncomms6601.; Liyanage VR, Zachariah RM, Rastegar M. Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells. Molecular Autism. 2013 Nov 15;4(1):46. doi: 10.1186/2040-2392-4-46.; McFarland KN, Huizenga MN, Darnell SB, Sangrey GR, Berezovska O, Cha J-J, Outeiro TF, Sadri-Vakili G. MeCP2: a novel Huntingtin interactor. Human Molecular Genetics. 2013 Oct 08;23(4):1036–44. doi: 10.1093/hmg/ddt499.; Ebert DH, Gabel HW, Robinson ND, Kastan NR, Hu LS, Cohen S, Navarro AJ, Lyst MJ, Ekiert R, Bird AP, Greenberg ME. Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR. Nature. 2013 Jul 18;499(7458):341–5. PMID: 23770587; PMCID: PMC3922283.; Lyst MJ, Ekiert R, Ebert DH, Merusi C, Nowak J, Selfridge J, Guy J, Kastan NR, Robinson ND, de Lima Alves F, Rappsilber J, Greenberg ME, Bird A. Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Nat Neurosci. 2013 Jul;16(7):898–902. PMID: 23770565; PMCID: PMC3786392.; Chen Y, Shin BC, Thamotharan S, Devaskar SU. Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression. Endocrinology. 2013 Apr;154(4):1598–611. PMID: 23493374; PMCID: PMC3602632.; Dastidar SG, Bardai FH, Ma C, Price V, Rawat V, Verma P, Narayanan V, D'Mello SR. Isoform-Specific Toxicity of Mecp2 in Postmitotic Neurons: Suppression of Neurotoxicity by FoxG1. J. Neurosci. 2012 Feb 22;32(8):2846–55. doi: 10.1523/jneurosci.5841-11.2012.; Qiu Z, Sylwestrak EL, Lieberman DN, Zhang Y, Liu X, Ghosh A. The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling. J. Neurosci. 2012 Jan 18;32(3):989–94. doi: 10.1523/jneurosci.0175-11.2012.; Franklin TB, Russig H, Weiss IC, Gräff J, Linder N, Michalon A, Vizi S, Mansuy IM. Epigenetic transmission of the impact of early stress across generations. Biol Psychiatry. 2010 Sep 01;68(5):408–15. doi: 10.1016/j.biopsych.2010.05.036. PMID: 20673872.; Bracaglia G, Conca B, Bergo A, Rusconi L, Zhou Z, Greenberg ME, Landsberger N, Soddu S, Kilstrup-Nielsen C. Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis. EMBO Reports. 2009 Oct 09;10(12):1327–33. doi: 10.1038/embor.2009.217.; Guarda A, Bolognese F, Bonapace IM, Badaracco G. Interaction between the inner nuclear membrane lamin B receptor and the heterochromatic methyl binding protein, MeCP2. Exp Cell Res. 2009 Jul 01;315(11):1895–903. doi: 10.1016/j.yexcr.2009.01.019. PMID: 19331822.; Tao J, Hu K, Chang Q, Wu H, Sherman NE, Martinowich K, Klose RJ, Schanen C, Jaenisch R, Wang W, Sun YE. Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882–7. PMID: 19225110; PMCID: PMC2660725.; Nagarajan RP, Patzel KA, Martin M, Yasui DH, Swanberg SE, Hertz-Picciotto I, Hansen RL, Van de Water J, Pessah IN, Jiang R, Robinson WP, LaSalle JM. MECP2 promoter methylation and X chromosome inactivation in autism. Autism Res. 2008 Jun;1(3):169–78. PMID: 19132145; PMCID: PMC2614877.; Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, Zoghbi HY. MeCP2, a key contributor to neurological disease, activates and represses transcription. Science. 2008 May 30;320(5880):1224–9. PMID: 18511691; PMCID: PMC2443785.; Klein ME, Lioy DT, Ma L, Impey S, Mandel G, Goodman RH. Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci. 2007 Dec;10(12):1513–4. doi: 10.1038/nn2010. PMID: 17994015.; Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, Schmidt L, Chen WG, Lin Y, Savner E, Griffith EC, Hu L, Steen JA, Weitz CJ, Greenberg ME. Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron. 2006 Oct 19;52(2):255–69. PMID: 17046689; PMCID: PMC3962021.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.5.1.-
1.3.1.70 DELTA14-sterol reductase 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ DELTA14-oxidoreductase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.17 Ca2+/calmodulin-dependent protein kinase ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
3.5.1.98 histone deacetylase histone amidohydrolase
3.6.4.13 RNA helicase


Proteins

Protein ID name full name