coenzyme A biosynthesis

Ruiz A, González A, Muñoz I, Serrano R, Abrie JA, Strauss E, Ariño J. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol. 2009 Dec;5(12):920–8. doi: 10.1038/nchembio.243. PMID: 19915539.; Rubio S, Larson TR, Gonzalez-Guzman M, Alejandro S, Graham IA, Serrano R, Rodriguez PL. An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment. Plant Physiol. 2006 Mar;140(3):830–43. PMID: 16415216; PMCID: PMC1400581.; Leonardi R, Zhang YM, Rock CO, Jackowski S. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar;44(2-3):125–53. doi: 10.1016/j.plipres.2005.04.001. PMID: 15893380.; Ruiz A, Muñoz I, Serrano R, González A, Simón E, Ariño J. Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. J Biol Chem. 2004 Aug 13;279(33):34421–30. doi: 10.1074/jbc.m400572200. PMID: 15192104.; Kupke T, Hernández-Acosta P, Culiáñez-Macià FA. 4'-Phosphopantetheine and Coenzyme A Biosynthesis in Plants. Journal of Biological Chemistry. 2003 Oct;278(40):38229–37. doi: 10.1074/jbc.m306321200.; Steinbacher S, Hernández-Acosta P, Bieseler B, Blaesse M, Huber R, Culiáñez-Macià FA, Kupke T. Crystal structure of the plant PPC decarboxylase AtHAL3a complexed with an ene-thiol reaction intermediate. J Mol Biol. 2003 Mar 14;327(1):193–202. doi: 10.1016/s0022-2836(03)00092-5. PMID: 12614618.; Ariño J. Novel protein phosphatases in yeast. European Journal of Biochemistry. 2002 Feb 15;269(4):1072–7. doi: 10.1046/j.0014-2956.2002.02753.x.; de Nadal E, Clotet J, Posas F, Serrano R, Gomez N, Ariño J. The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc. Natl. Acad. Sci. U.S.A. 1998 Jun 23;95(13):7357–62. doi: 10.1073/pnas.95.13.7357.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.24 dephospho-CoA kinase ATP:3'-dephospho-CoA 3'-phosphotransferase
2.7.7.3 pantetheine-phosphate adenylyltransferase ATP:pantetheine-4'-phosphate adenylyltransferase
6.3.2.5 phosphopantothenate-cysteine ligase (CTP) (R)-4'-phosphopantothenate:L-cysteine ligase


Proteins

Protein ID name full name
P40506 CAB2 Phosphopantothenate--cysteine ligase CAB2
P53332 CAB4 Phosphopantetheine adenylyltransferase
Q03941 CAB5 Dephospho-CoA kinase CAB5