Sphingolipid de novo biosynthesis

Gault CR, Obeid LM, Hannun YA. An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol. 2010;688():1–23. PMID: 20919643; PMCID: PMC3069696.; Merrill AH. De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway. Journal of Biological Chemistry. 2002 Jul;277(29):25843–6. doi: 10.1074/jbc.r200009200.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Cer(d18:0/16:0)

Formula: C34H69NO3 (539.5277164)

CAS ID: 5966-29-0

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.14.18.-
1.1.1.102 3-dehydrosphinganine reductase D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase
1.14.18.5 sphingolipid C4-monooxygenase dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
1.14.19.17 sphingolipid 4-desaturase dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating)
2.3.1.50 serine C-palmitoyltransferase palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
2.7.1.91 sphingosine kinase ATP:sphingoid base 1-phosphotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.8.27 sphingomyelin synthase ceramide:phosphatidylcholine cholinephosphotransferase
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.4.62 phosphatidylethanolamine phospholipase C phosphatidylethanolamine ethanolaminephosphohydrolase


Proteins

Protein ID name full name