L-threonine degradation I

Heßlinger C, Fairhurst SA, Sawers G. Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate. Molecular Microbiology. 1998 Feb;27(2):477–92. doi: 10.1046/j.1365-2958.1998.00696.x.; Bell SC, Turner JM. Bacterial catabolism of threonine. Threonine degradation initiated by l-threonine hydrolyase (deaminating) in a species of Corynebacterium. Biochem J. 1977 Jun 15;164(3):579–87. PMID: 16743051; PMCID: PMC1164834.; Shizuta Y, Hayaishi O. Regulation of Biodegradative Threonine Deaminase Synthesis in Escherichia coli by Cyclic Adenosine 3',5'-Monophosphate. Journal of Biological Chemistry. 1970 Oct;245(20):5416–23. doi: 10.1016/s0021-9258(18)62771-1.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

2-oxobutanoate

Formula: C4H5O3 (101.02386800000001)

CAS ID:

propionate

Formula: C3H5O2 (73.028953)

CAS ID: 72-03-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.-
2.3.1.54 formate C-acetyltransferase acetyl-CoA:formate C-acetyltransferase
2.3.1.8 phosphate acetyltransferase acetyl-CoA:phosphate acetyltransferase
2.7.2.1 acetate kinase ATP:acetate phosphotransferase
2.7.2.15 propionate kinase ATP:propanoate phosphotransferase


Proteins

Protein ID name full name
P09373 pflB Formate acetyltransferase 1
P0A6A3 ackA Acetate kinase
P0A9M8 pta Phosphate acetyltransferase
P11868 tdcD Propionate kinase
P42632 tdcE PFL-like enzyme TdcE