Metabolism of steroid hormones

Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.

Metabolites

11-Deoxycortisol

Formula: C21H30O4 (346.214398)

CAS ID: 152-58-9

4-Methylpentanal

Formula: C6H12O (100.0888102)

CAS ID: 1119-16-0

Acetaldehyde

Formula: C2H4O (44.0262134)

CAS ID: 75-07-0

Androstenedione

Formula: C19H26O2 (286.1932696)

CAS ID: 63-05-8

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

Cortisol

Formula: C21H30O5 (362.209313)

CAS ID: 50-23-7

Cortisone

Formula: C21H28O5 (360.1936638)

CAS ID: 53-06-5

Dehydroepiandrosterone

Formula: C19H28O2 (288.2089188)

CAS ID: 53-43-0

Dihydrotestosterone

Formula: C19H30O2 (290.224568)

CAS ID: 521-18-6

Estradiol-17beta

Formula: C18H24O2 (272.17762039999997)

CAS ID: 50-28-2

Estrone

Formula: C18H22O2 (270.1619712)

CAS ID: 53-16-7

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pregnenolone

Formula: C21H32O2 (316.24021719999996)

CAS ID: 145-13-1

Progesterone

Formula: C21H30O2 (314.224568)

CAS ID: 57-83-0

Sulfate

Formula: H2SO4 (97.9673812)

CAS ID: 7664-93-9

Testosterone

Formula: C19H28O2 (288.2089188)

CAS ID: 58-22-0

Isohexanol

Formula: C6H14O (102.10445940000001)

CAS ID: 1320-98-5

pregn-5-ene-3,20-dione

Formula: C21H30O2 (314.224568)

CAS ID: 1236-09-5

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

22S-hydroxycholesterol

Formula: C27H46O2 (402.34976159999997)

CAS ID: 22348-64-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.14.14.14 aromatase testosterone monooxygenase (17beta-estradiol-forming)
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) 3-oxo-5alpha-steroid:NADP+ DELTA4-oxidoreductase
1.3.1.94 polyprenal reductase dolichal:NADP+ 2,3-oxidoreductase


Proteins

Protein ID name full name