Sphingolipid metabolism

Groux-Degroote S, Guérardel Y, Delannoy P. Gangliosides: Structures, Biosynthesis, Analysis, and Roles in Cancer. Chembiochem. 2017 Jul 04;18(13):1146–54. doi: 10.1002/cbic.201600705. PMID: 28295942.; Saito S, Matsui H, Kawano M, Kumagai K, Tomishige N, Hanada K, Echigo S, Tamura S, Kobayashi T. Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes. J Biol Chem. 2008 Mar 07;283(10):6584–93. doi: 10.1074/jbc.m707691200. PMID: 18165232.; Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nature Reviews Molecular Cell Biology. 2008 Feb;9(2):139–50. doi: 10.1038/nrm2329.; Merrill AH. De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway. Journal of Biological Chemistry. 2002 Jul;277(29):25843–6. doi: 10.1074/jbc.r200009200.

Metabolites

alpha-D-Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 3646-73-9

Choline phosphate

Formula: C5H15NO4P (184.07386599999998)

CAS ID: 107-73-3

D-Glucose

Formula: C6H12O6 (180.0633852)

CAS ID: 50-99-7

Ethanolamine phosphate

Formula: C2H8NO4P (141.0190938)

CAS ID: 1071-23-4

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hexadecanal

Formula: C16H32O (240.2453022)

CAS ID: 629-80-1

Hexadecenal

Formula: C16H30O (238.22965299999998)

CAS ID: 3163-37-9

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

N-Acetyl-D-galactosamine

Formula: C8H15NO6 (221.089933)

CAS ID: 14215-68-0

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Cer(d18:0/16:0)

Formula: C34H69NO3 (539.5277164)

CAS ID: 5966-29-0

Sphingosine(1+)

Formula: C18H38NO2 (300.2902388)

CAS ID:

hexadecanoate

Formula: C16H31O2 (255.2323926)

CAS ID: 143-20-4

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

UDP-N-acetyl-D-galactosamine(2-)

Formula: C17H25N3O17P2 (605.0659180000001)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.7.8.-
1.14.19.17 sphingolipid 4-desaturase dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating)
2.4.1.80 ceramide glucosyltransferase UDP-glucose:N-acylsphingosine D-glucosyltransferase
2.7.1.138 ceramide kinase ATP:ceramide 1-phosphotransferase
2.7.1.91 sphingosine kinase ATP:sphingoid base 1-phosphotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.8.27 sphingomyelin synthase ceramide:phosphatidylcholine cholinephosphotransferase
3.1.4.12 sphingomyelin phosphodiesterase sphingomyelin cholinephosphohydrolase
3.2.1.45 glucosylceramidase D-glucosyl-N-acylsphingosine glucohydrolase
3.2.1.46 galactosylceramidase D-galactosyl-N-acylsphingosine galactohydrolase
3.5.1.23 ceramidase N-acylsphingosine amidohydrolase
4.1.2.27 sphinganine-1-phosphate aldolase sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)


Proteins

Protein ID name full name