D-myo-inositol (1,4,5)-trisphosphate biosynthesis

Streb H, Irvine RF, Berridge MJ, Schulz I. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature. 1983 Nov;306(5938):67–9. doi: 10.1038/306067a0. PMID: 6605482.

Metabolites

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

myo-Inositol

Formula: C6H12O6 (180.0633852)

CAS ID: 87-89-8

Wortmannin

Formula: C23H24O8 (428.1471104)

CAS ID: 19545-26-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

Phosphatidylinositol 4-phosphate

Formula: C11H20O16P2 (470.02265800000004)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase
2.7.1.67 1-phosphatidylinositol 4-kinase ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase
2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
2.7.8.11 CDP-diacylglycerol-inositol 3-phosphatidyltransferase CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
3.1.4.11 phosphoinositide phospholipase C 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase


Proteins

Protein ID name full name
P06197 PIS1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase