Assembly of the pre-replicative complex

Dimitrova DS, Prokhorova TA, Blow JJ, Todorov IT, Gilbert DM. Mammalian nuclei become licensed for DNA replication during late telophase. J Cell Sci. 2002 Jan 01;115(Pt 1):51–9. PMID: 11801723; PMCID: PMC1255924.; Méndez J, Stillman B. Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis. Molecular and Cellular Biology. 2000 Nov 01;20(22):8602–12. doi: 10.1128/mcb.20.22.8602-8612.2000.; Neuwald AF, Aravind L, Spouge JL, Koonin EV. AAA+: A Class of Chaperone-Like ATPases Associated with the Assembly, Operation, and Disassembly of Protein Complexes. Genome Res. 1999 Jan 01;9(1):27–43. doi: 10.1101/gr.9.1.27.; Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B. The Orc4p and Orc5p Subunits of the Xenopus and Human Origin Recognition Complex Are Related to Orc1p and Cdc6p. Journal of Biological Chemistry. 1998 Dec;273(49):32421–9. doi: 10.1074/jbc.273.49.32421.; Liang C, Stillman B. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev. 1997 Dec 15;11(24):3375–86. doi: 10.1101/gad.11.24.3375.; Aparicio OM, Weinstein DM, Bell SP. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell. 1997 Oct 03;91(1):59–69. doi: 10.1016/s0092-8674(01)80009-x. PMID: 9335335.; Tanaka T, Knapp D, Nasmyth K. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell. 1997 Aug 22;90(4):649–60. doi: 10.1016/s0092-8674(00)80526-7. PMID: 9288745.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
3.6.4.12 DNA helicase
5.6.2.4 DNA 3'-5' helicase DNA 3'-5' helicase (ATP-hydrolysing)


Proteins

Protein ID name full name