sphingolipid biosynthesis (mammals)

Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC. Identification of a family of animal sphingomyelin synthases. EMBO J. 2004 Jan 14;23(1):33–44. PMID: 14685263; PMCID: PMC1271672.; Hanada K. Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2003 Jun;1632(1-3):16–30. doi: 10.1016/s1388-1981(03)00059-3.; Michel C, van Echten-Deckert G, Rother J, Sandhoff K, Wang E, Merrill AH. Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. J Biol Chem. 1997 Sep 05;272(36):22432–7. doi: 10.1074/jbc.272.36.22432. PMID: 9312549.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Dihydroceramide

Formula: C19H39NO3 (329.29297840000004)

CAS ID:

3-dehydrosphinganinium(1+)

Formula: C18H38NO2 (300.2902388)

CAS ID:

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
5.2.1.-
1.1.1.102 3-dehydrosphinganine reductase D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase
1.14.19.17 sphingolipid 4-desaturase dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating)
2.3.1.299 sphingoid base N-stearoyltransferase stearoyl-CoA:sphingoid base N-stearoyltransferase
2.3.1.50 serine C-palmitoyltransferase palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
2.7.8.27 sphingomyelin synthase ceramide:phosphatidylcholine cholinephosphotransferase


Proteins

Protein ID name full name