Transcriptional Regulation by TP53

Kruiswijk F, Labuschagne CF, Vousden KH. p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nature Reviews Molecular Cell Biology. 2015 Jun 23;16(7):393–405. doi: 10.1038/nrm4007.; Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell. 2009 May 01;137(3):413–31. doi: 10.1016/j.cell.2009.04.037. PMID: 19410540.

Metabolites

1,2-Naphthoquinone

Formula: C10H6O2 (158.0367776)

CAS ID: 524-42-5

CO

Formula: CO (27.994915)

CAS ID: 630-08-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

6-O-phosphonato-D-glucono-1,5-lactone(2-)

Formula: C6H9O9P (255.99841940000002)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.1.1.-
1.11.1.2 NADPH peroxidase NADPH:hydrogen-peroxide oxidoreductase
1.11.1.24 thioredoxin-dependent peroxiredoxin thioredoxin:hydroperoxide oxidoreductase
1.8.1.9 thioredoxin-disulfide reductase thioredoxin:NADP+ oxidoreductase
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
2.1.1.361 [histone H4]-lysine20 N-methyltransferase S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-methyltransferase
2.5.1.60 protein geranylgeranyltransferase type II geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.5.1.98 histone deacetylase histone amidohydrolase
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase
5.3.1.9 glucose-6-phosphate isomerase alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)
5.6.2.3 DNA 5'-3' helicase DNA 5'-3' helicase (ATP-hydrolysing)
5.6.2.4 DNA 3'-5' helicase DNA 3'-5' helicase (ATP-hydrolysing)


Proteins

Protein ID name full name