Transcriptional Regulation by E2F6

Bertoli C, Herlihy AE, Pennycook BR, Kriston-Vizi J, de Bruin RAM. Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage. Cell Reports. 2016 May;15(7):1412–22. doi: 10.1016/j.celrep.2016.04.036.; Bertoli C, Klier S, McGowan C, Wittenberg C, de Bruin RM. Chk1 Inhibits E2F6 Repressor Function in Response to Replication Stress to Maintain Cell-Cycle Transcription. Current Biology. 2013 Sep;23(17):1629–37. doi: 10.1016/j.cub.2013.06.063.; Trojer P, Cao A, Gao Z, Li Y, Zhang J, Xu X, Li G, Losson R, Erdjument-Bromage H, Tempst P, Farnham P, Reinberg D. L3MBTL2 Protein Acts in Concert with PcG Protein-Mediated Monoubiquitination of H2A to Establish a Repressive Chromatin Structure. Molecular Cell. 2011 May;42(4):438–50. doi: 10.1016/j.molcel.2011.04.004.; Giangrande PH, Zhu W, Schlisio S, Sun X, Mori S, Gaubatz S, Nevins JR. A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Genes Dev. 2004 Dec 01;18(23):2941–51. PMID: 15574595; PMCID: PMC534654.; Oberley MJ, Inman DR, Farnham PJ. E2F6 Negatively Regulates BRCA1 in Human Cancer Cells without Methylation of Histone H3 on Lysine 9. Journal of Biological Chemistry. 2003 Oct;278(43):42466–76. doi: 10.1074/jbc.m307733200.; Storre J, Elsässer H, Fuchs M, Ullmann D, Livingston DM, Gaubatz S. Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6. EMBO Reports. 2002 Jul;3(7):695–700. doi: 10.1093/embo-reports/kvf141.; Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science. 2002 May 10;296(5570):1132–6. doi: 10.1126/science.1069861. PMID: 12004135.; Cartwright P, Müller H, Wagener C, Holm K, Helin K. E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene. 1998 Aug 06;17(5):611–23. doi: 10.1038/sj.onc.1201975. PMID: 9704927.; Gaubatz S, Wood JG, Livingston DM. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc. Natl. Acad. Sci. U.S.A. 1998 Aug 04;95(16):9190–5. doi: 10.1073/pnas.95.16.9190.; Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc. Natl. Acad. Sci. U.S.A. 1998 Mar 17;95(6):2850–5. doi: 10.1073/pnas.95.6.2850.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)


Proteins

Protein ID name full name