MASTL Facilitates Mitotic Progression

Blake-Hodek KA, Williams BC, Zhao Y, Castilho PV, Chen W, Mao Y, Yamamoto TM, Goldberg ML. Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry. Molecular and Cellular Biology. 2012 Apr 01;32(8):1337–53. doi: 10.1128/mcb.06525-11.; Vigneron S, Gharbi-Ayachi A, Raymond A, Burgess A, Labbé J, Labesse G, Monsarrat B, Lorca T, Castro A. Characterization of the Mechanisms Controlling Greatwall Activity. Molecular and Cellular Biology. 2011 Jun 01;31(11):2262–75. doi: 10.1128/mcb.00753-10.; Mochida S, Maslen SL, Skehel M, Hunt T. Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science. 2010 Dec 17;330(6011):1670–3. doi: 10.1126/science.1195689. PMID: 21164013.; Gharbi-Ayachi A, Labbé JC, Burgess A, Vigneron S, Strub JM, Brioudes E, Van-Dorsselaer A, Castro A, Lorca T. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Science. 2010 Dec 17;330(6011):1673–7. doi: 10.1126/science.1197048. PMID: 21164014.; Burgess A, Vigneron S, Brioudes E, Labbé JC, Lorca T, Castro A. Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12564–9. PMID: 20538976; PMCID: PMC2906566.; Yu J, Zhao Y, Li Z, Galas S, Goldberg ML. Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts. Mol Cell. 2006 Apr 07;22(1):83–91. doi: 10.1016/j.molcel.2006.02.022. PMID: 16600872.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)


Proteins

Protein ID name full name
P43565 RIM15 Serine/threonine-protein kinase RIM15