Extra-nuclear estrogen signaling

Sampayo RG, Toscani AM, Rubashkin MG, Thi K, Masullo LA, Violi IL, Lakins JN, Cáceres A, Hines WC, Coluccio Leskow F, Stefani FD, Chialvo DR, Bissell MJ, Weaver VM, Simian M. Fibronectin rescues estrogen receptor a from lysosomal degradation in breast cancer cells. J Cell Biol. 2018 Aug 06;217(8):2777–98. PMID: 29980625; PMCID: PMC6080927.; Arnal JF, Lenfant F, Metivier R, Flouriot G, Henrion D, Adlanmerini M, Fontaine C, Gourdy P, Chambon P, Katzenellenbogen B, Katzenellenbogen J. Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications. Physiol Rev. 2017 Jul 01;97(3):1045–87. doi: 10.1152/physrev.00024.2016. PMID: 28539435.; Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD. Rapid steroid hormone actions via membrane receptors. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016 Sep;1863(9):2289–98. doi: 10.1016/j.bbamcr.2016.06.004.; La Rosa P, Pesiri V, Leclercq G, Marino M, Acconcia F. Palmitoylation Regulates 17ß-Estradiol-Induced Estrogen Receptor-a Degradation and Transcriptional Activity. Molecular Endocrinology. 2012 May;26(5):762–74. doi: 10.1210/me.2011-1208.; Pedram A, Razandi M, Deschenes RJ, Levin ER. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Mol Biol Cell. 2012 Jan;23(1):188–99. PMID: 22031296; PMCID: PMC3248897.; Handa RJ, Ogawa S, Wang JM, Herbison AE. Roles for Oestrogen Receptor ß in Adult Brain Function. J Neuroendocrinology. 2011 Dec 20;24(1):160–73. doi: 10.1111/j.1365-2826.2011.02206.x.; Hammes SR, Levin ER. Minireview: Recent advances in extranuclear steroid receptor actions. Endocrinology. 2011 Dec;152(12):4489–95. PMID: 22028449; PMCID: PMC3858720.; Le Romancer M, Poulard C, Cohen P, Sentis S, Renoir JM, Corbo L. Cracking the estrogen receptor's posttranslational code in breast tumors. Endocr Rev. 2011 Oct;32(5):597–622. doi: 10.1210/er.2010-0016. PMID: 21680538.; Boonyaratanakornkit V. Scaffolding proteins mediating membrane-initiated extra-nuclear actions of estrogen receptor. Steroids. 2011 Aug;76(9):877–84. doi: 10.1016/j.steroids.2011.02.017. PMID: 21354435.; Le Romancer M, Treilleux I, Leconte N, Robin-Lespinasse Y, Sentis S, Bouchekioua-Bouzaghou K, Goddard S, Gobert-Gosse S, Corbo L. Regulation of estrogen rapid signaling through arginine methylation by PRMT1. Mol Cell. 2008 Jul 25;31(2):212–21. doi: 10.1016/j.molcel.2008.05.025. PMID: 18657504.; Hammes SR, Levin ER. Extranuclear steroid receptors: nature and actions. Endocr Rev. 2007 Dec;28(7):726–41. doi: 10.1210/er.2007-0022. PMID: 17916740.; Pedram A, Razandi M, Sainson RCA, Kim JK, Hughes CC, Levin ER. A Conserved Mechanism for Steroid Receptor Translocation to the Plasma Membrane. Journal of Biological Chemistry. 2007 Aug;282(31):22278–88. doi: 10.1074/jbc.m611877200.; Lange CA, Gioeli D, Hammes SR, Marker PC. Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer. Annu Rev Physiol. 2007;69():171–99. doi: 10.1146/annurev.physiol.69.031905.160319. PMID: 17037979.; Marino M, Ascenzi P. Steroid hormone rapid signaling: the pivotal role of S-palmitoylation. IUBMB Life. 2006 Dec;58(12):716–9. doi: 10.1080/15216540601019485. PMID: 17424910.; Marino M, Ascenzi P, Acconcia F. S-palmitoylation modulates estrogen receptor alpha localization and functions. Steroids. 2006 Apr;71(4):298–303. doi: 10.1016/j.steroids.2005.09.011. PMID: 16274718.; Biswas DK, Singh S, Shi Q, Pardee AB, Iglehart JD. Crossroads of estrogen receptor and NF-kappaB signaling. Sci STKE. 2005 Jun 14;2005(288):pe27. doi: 10.1126/stke.2882005pe27. PMID: 15956359.; Acconcia F, Ascenzi P, Bocedi A, Spisni E, Tomasi V, Trentalance A, Visca P, Marino M. Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. Mol Biol Cell. 2005 Jan;16(1):231–7. PMID: 15496458; PMCID: PMC539167.; Acconcia F, Ascenzi P, Fabozzi G, Visca P, Marino M. S-palmitoylation modulates human estrogen receptor-a functions. Biochemical and Biophysical Research Communications. 2004 Apr;316(3):878–83. doi: 10.1016/j.bbrc.2004.02.129.; Farach-Carson MC, Davis PJ. Steroid Hormone Interactions with Target Cells: Cross Talk between Membrane and Nuclear Pathways. The Journal of Pharmacology and Experimental Therapeutics. 2003 Dec;307(3):839–45. doi: 10.1124/jpet.103.055038.; Lösel R, Wehling M. Nongenomic actions of steroid hormones. Nature Reviews Molecular Cell Biology. 2003 Jan;4(1):46–55. doi: 10.1038/nrm1009.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nitric oxide

Formula: NO (29.997989)

CAS ID: 10102-43-9

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

L-argininium(1+)

Formula: C6H15N4O2 (175.119495)

CAS ID: 17806-42-7

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.7.10.1 receptor protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name