superpathway of 4-aminobutanoate degradation

Romagnoli G, Verhoeven MD, Mans R, Fleury Rey Y, Bel-Rhlid R, van den Broek M, Maleki Seifar R, Ten Pierick A, Thompson M, Müller V, Wahl SA, Pronk JT, Daran JM. An alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme. Molecular Microbiology. 2014 Jun 23;93(2):369–89. doi: 10.1111/mmi.12666.; Dover S, Halpern YS. Utilization of ?-Aminobutyric Acid as the Sole Carbon and Nitrogen Source by Escherichia coli K-12 Mutants. J Bacteriol. 1972 Feb;109(2):835–43. doi: 10.1128/jb.109.2.835-843.1972.

Metabolites

3-Methylbenzaldehyde

Formula: C8H8O (120.0575118)

CAS ID: 620-23-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydroxylamine

Formula: NH3O (33.0214628)

CAS ID: 7803-49-8

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

N-Ethylmaleimide

Formula: C6H7NO2 (125.0476762)

CAS ID: 128-53-0

Phenylhydrazine

Formula: C6H8N2 (108.06874479999999)

CAS ID: 100-63-0

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.2.1.-
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+] succinate-semialdehyde:NAD(P)+ oxidoreductase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+] aldehyde:NAD(P)+ oxidoreductase
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+) succinate-semialdehyde:NADP+ oxidoreductase
2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase 4-aminobutanoate:2-oxoglutarate aminotransferase
2.6.1.48 5-aminovalerate transaminase 5-aminopentanoate:2-oxoglutarate aminotransferase


Proteins

Protein ID name full name
P22256 gabT 4-aminobutyrate aminotransferase GabT
P23883 puuC NADP/NAD-dependent aldehyde dehydrogenase PuuC
P25526 gabD Succinate-semialdehyde dehydrogenase [NADP(+)] GabD
P50457 puuE 4-aminobutyrate aminotransferase PuuE
P76149 sad Succinate semialdehyde dehydrogenase [NAD(P)+] Sad