Iron assimilation using enterobactin

Barber MF, Elde NC. Buried Treasure: Evolutionary Perspectives on Microbial Iron Piracy. Trends in Genetics. 2015 Nov;31(11):627–36. doi: 10.1016/j.tig.2015.09.001.; Miethke M, Marahiel MA. Siderophore-based iron acquisition and pathogen control. Microbiol Mol Biol Rev. 2007 Sep;71(3):413–51. PMID: 17804665; PMCID: PMC2168645.

Metabolites

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

N-(2,3-dihydroxybenzoyl)-L-serinate

Formula: C10H10NO6 (240.05081)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

Ferrienterochelin

Formula: C30H27FeN3O15 (725.0791502000001)

CAS ID:



Enzyme

EC Number name full name note
1.16.1.9 ferric-chelate reductase (NADPH) Fe(II)-siderophore:NADP+ oxidoreductase
3.1.1.108 iron(III)-enterobactin esterase iron(III)-enterobactin hydrolase
7.2.2.17 ABC-type ferric enterobactin transporter ATP phosphohydrolase (ABC-type, iron(III) enterobactin-importing)


Proteins

Protein ID name full name
P13039 fes Iron(III) enterobactin esterase
P23878 fepC Ferric enterobactin transport ATP-binding protein FepC
Q46871 yqjH NADPH-dependent ferric-chelate reductase