DAG1 glycosylations

ENDO T. Mammalian O-mannosyl glycans: Biochemistry and glycopathology. Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences. 2019 Jan 11;95(1):39–51. doi: 10.2183/pjab.95.004.; Endo T. Glycobiology of -dystroglycan and muscular dystrophy. Journal of Biochemistry. 2014 Nov 07;157(1):1–12. doi: 10.1093/jb/mvu066.; Praissman JL, Wells L. Mammalian O-mannosylation pathway: glycan structures, enzymes, and protein substrates. Biochemistry. 2014 May 20;53(19):3066–78. PMID: 24786756; PMCID: PMC4033628.; Live D, Wells L, Boons GJ. Dissecting the molecular basis of the role of the O-mannosylation pathway in disease: a-dystroglycan and forms of muscular dystrophy. Chembiochem. 2013 Dec 16;14(18):2392–402. PMID: 24318691; PMCID: PMC3938021.; Wells L. The O-Mannosylation Pathway: Glycosyltransferases and Proteins Implicated in Congenital Muscular Dystrophy. Journal of Biological Chemistry. 2013 Mar;288(10):6930–5. doi: 10.1074/jbc.r112.438978.; Sparks SE. Congenital protein hypoglycosylation diseases. Appl Clin Genet. 2012;5():43–54. PMID: 23776380; PMCID: PMC3681192.; Tran DT, Lim JM, Liu M, Stalnaker SH, Wells L, Ten Hagen KG, Live D. Glycosylation of a-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases. J Biol Chem. 2012 Jun 15;287(25):20967–74. PMID: 22549772; PMCID: PMC3375520.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.4.1.-
2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase
2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)-beta-D-mannosyl-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
2.4.1.312 protein O-mannose beta-1,4-N-acetylglucosaminyltransferase UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-threonyl-[protein] 4-beta-N-acetyl-D-glucosaminyltransferase
2.4.1.313 protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl-threonyl-[protein] 3-beta-N-acetyl-D-galactosaminyltransferase
2.4.2.61 alpha-dystroglycan beta1,4-xylosyltransferase UDP-alpha-D-xylose:3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man]-Ser/Thr-[protein] xylosyltransferase
2.7.1.183 glycoprotein-mannosyl O6-kinase ATP:O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase
2.7.7.40 D-ribitol-5-phosphate cytidylyltransferase CTP:D-ribitol-5-phosphate cytidylyltransferase


Proteins

Protein ID name full name