Signaling by TGFBR3

Song H, Yang J, Yu W. Promoter Hypomethylation of TGFBR3 as a Risk Factor of Alzheimer's Disease: An Integrated Epigenomic-Transcriptomic Analysis. Front Cell Dev Biol. 2021;9():825729. PMID: 35310542; PMCID: PMC8924075.; Santiago RP, Figueiredo CVB, Fiuza LM, Yahouédéhou SCMA, Oliveira RM, Aleluia MM, Carvalho SP, Fonseca CA, Nascimento VML, Rocha LC, Guarda CC, Gonçalves MS. Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations. Mediators of Inflammation. 2020 Oct 13;2020():1–18. doi: 10.1155/2020/3185015.; Zhang J, ten Dijke P, Wuhrer M, Zhang T. Role of glycosylation in TGF-ß signaling and epithelial-to-mesenchymal transition in cancer. Protein & Cell. 2020 Jun 25;12(2):89–106. doi: 10.1007/s13238-020-00741-7.; Cook LM, Frieling JS, Nerlakanti N, McGuire JJ, Stewart PA, Burger KL, Cleveland JL, Lynch CC. Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis. Oncogene. 2019 Aug 13;38(44):6959–69. doi: 10.1038/s41388-019-0913-4.; Knelson EH, Gaviglio AL, Tewari AK, Armstrong MB, Mythreye K, Blobe GC. Type III TGF-ß receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma. J Clin Invest. 2013 Nov;123(11):4786–98. PMID: 24216509; PMCID: PMC3809791.; Sánchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, Brown CB, Czirok A, Camenisch TD, Barnett JV. The cytoplasmic domain of TGFßR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior. Developmental Biology. 2011 Oct;358(2):331–43. doi: 10.1016/j.ydbio.2011.08.008.; Blair CR, Stone JB, Wells RG. The type III TGF-ß receptor betaglycan transmembrane–cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease ?-secretase. 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Journal of Biological Chemistry. 2004 Feb;279(9):7721–33. doi: 10.1074/jbc.m306499200.; Wiater E, Vale W. Inhibin Is an Antagonist of Bone Morphogenetic Protein Signaling. Journal of Biological Chemistry. 2003 Mar;278(10):7934–41. doi: 10.1074/jbc.m209710200.; Lopez-Casillas F, Riquelme C, Perez-Kato Y, Ponce-Castaneda MV, Osses N, Esparza-Lopez J, Gonzalez-Nunez G, Cabello-Verrugio C, Mendoza V, Troncoso V, Brandan E. Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta. J Biol Chem. 2003 Jan 03;278(1):382–90. doi: 10.1074/jbc.m208520200. PMID: 12399463.; Blobe GC, Liu X, Fang SJ, How T, Lodish HF. A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. J Biol Chem. 2001 Oct 26;276(43):39608–17. doi: 10.1074/jbc.m106831200. PMID: 11546783.; Blobe GC, Schiemann WP, Pepin MC, Beauchemin M, Moustakas A, Lodish HF, O'Connor-McCourt MD. Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling. J Biol Chem. 2001 Jul 06;276(27):24627–37. doi: 10.1074/jbc.m100188200. PMID: 11323414.; Esparza-Lopez J, Montiel JL, Vilchis-Landeros MM, Okadome T, Miyazono K, López-Casillas F. Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-beta superfamily. Specialized binding regions for transforming growth factor-beta and inhibin A. J Biol Chem. 2001 May 04;276(18):14588–96. doi: 10.1074/jbc.m008866200. PMID: 11278442.; López-Casillas F, Payne HM, Andres JL, Massagué J. Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. 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Metabolites

Retinoate

Formula: C20H28O2 (300.2089188)

CAS ID: 302-79-4

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.-
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.7.11.30 receptor protein serine/threonine kinase ATP:[receptor-protein] phosphotransferase
3.6.4.13 RNA helicase


Proteins

Protein ID name full name