High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Xiao R, Liu J, Shawn Xu XZ. Mechanosensitive GPCRs and ion channels in shear stress sensing. Current Opinion in Cell Biology. 2023 Oct;84():102216. doi: 10.1016/j.ceb.2023.102216.; Tamargo IA, Baek KI, Kim Y, Park C, Jo H. Flow-induced reprogramming of endothelial cells in atherosclerosis. Nat Rev Cardiol. 2023 May 24;20(11):738–53. doi: 10.1038/s41569-023-00883-1.; Cabou C, Martinez LO. The Interplay of Endothelial P2Y Receptors in Cardiovascular Health: From Vascular Physiology to Pathology. Int J Mol Sci. 2022 May 24;23(11). PMID: 35682562; PMCID: PMC9180512.; Tanaka K, Joshi D, Timalsina S, Schwartz MA. Early events in endothelial flow sensing. Cytoskeleton (Hoboken). 2021 Jun;78(6):217–31. doi: 10.1002/cm.21652. PMID: 33543538.; Fang XZ, Zhou T, Xu JQ, Wang YX, Sun MM, He YJ, Pan SW, Xiong W, Peng ZK, Gao XH, Shang Y. Structure, kinetic properties and biological function of mechanosensitive Piezo channels. Cell Biosci. 2021 Jan 09;11(1):13. PMID: 33422128; PMCID: PMC7796548.; Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016 Dec 01;126(12):4527–36. PMID: 27797339; PMCID: PMC5127677.; Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ. Piezo1 integration of vascular architecture with physiological force. Nature. 2014 Nov 13;515(7526):279–82. PMID: 25119035; PMCID: PMC4230887.; Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A. Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10347–52. PMID: 24958852; PMCID: PMC4104881.; Félétou M, Köhler R, Vanhoutte PM. Nitric oxide: orchestrator of endothelium-dependent responses. Ann Med. 2012 Nov;44(7):694–716. doi: 10.3109/07853890.2011.585658. PMID: 21895549.; Feletou M, Tang EH, Vanhoutte PM. Nitric oxide the gatekeeper of endothelial vasomotor control. Front Biosci. 2008 May 01;13():4198–217. doi: 10.2741/3000. PMID: 18508506.; Miyazaki T, Honda K, Ohata H. Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity. American Journal of Physiology-Cell Physiology. 2007 Oct;293(4):C1216–25. doi: 10.1152/ajpcell.00083.2007.; Nerem RM, Levesque MJ, Cornhill JF. Vascular endothelial morphology as an indicator of the pattern of blood flow. J Biomech Eng. 1981 Aug;103(3):172–6. doi: 10.1115/1.3138275. PMID: 7278195.; Dewey CF, Bussolari SR, Gimbrone MA, Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng. 1981 Aug;103(3):177–85. doi: 10.1115/1.3138276. PMID: 7278196.