Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes

Lee J, Cho Y, Deng C, Ge K. MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPß and C/EBPd. Molecular and Cellular Biology. 2020 Aug 14;40(17). doi: 10.1128/mcb.00209-20.; Jang Y, Broun A, Wang C, Park YK, Zhuang L, Lee JE, Froimchuk E, Liu C, Ge K. H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development. Nucleic Acids Res. 2019 Jan 25;47(2):607–20. PMID: 30335158; PMCID: PMC6344897.; Abood S, Veisaga ML, López LA, Barbieri MA. Dehydroleucodine inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest. Phytother Res. 2018 Aug;32(8):1583–92. doi: 10.1002/ptr.6089. PMID: 29663555.; Lee J, Park Y, Park S, Jang Y, Waring N, Dey A, Ozato K, Lai B, Peng W, Ge K. Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis. Nature Communications. 2017 Dec 20;8(1):2217. doi: 10.1038/s41467-017-02403-5.; Jang MK, Yun YR, Kim JH, Park MH, Jung MH. Gomisin N inhibits adipogenesis and prevents high-fat diet-induced obesity. Sci Rep. 2017 Jan 09;7():40345. PMID: 28067305; PMCID: PMC5220372.; Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S, Lee JW. Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPAR?2. Cell Rep. 2016 Nov 01;17(6):1671–82. doi: 10.1016/j.celrep.2016.10.023. PMID: 27806304.; Son MJ, Kim WK, Oh K, Park A, Lee DS, Han BS, Lee SC, Bae K. Methyltransferase and demethylase profiling studies during brown adipocyte differentiation. BMB Reports. 2016 Jul 31;49(7):388–93. doi: 10.5483/bmbrep.2016.49.7.062.; Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W, Ge K. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife. 2013 Dec 24;2():e01503. PMID: 24368734; PMCID: PMC3869375.; Lee J, Saha PK, Yang QH, Lee S, Park JY, Suh Y, Lee SK, Chan L, Roeder RG, Lee JW. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A. 2008 Dec 09;105(49):19229–34. PMID: 19047629; PMCID: PMC2614744.; Lee S, Lee J, Lee S, Lee JW. Activating Signal Cointegrator-2 Is an Essential Adaptor to Recruit Histone H3 Lysine 4 Methyltransferases MLL3 and MLL4 to the Liver X Receptors. Molecular Endocrinology. 2008 Jun;22(6):1312–9. doi: 10.1210/me.2008-0012.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)


Proteins

Protein ID name full name