Ribavirin ADME

Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. Journal of Pharmaceutical Sciences. 2016 Apr;105(4):1362–9. doi: 10.1016/j.xphs.2016.01.017.; Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cellular and Molecular Life Sciences. 2006 Feb 23;63(7-8):832–42. doi: 10.1007/s00018-005-5455-y.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.5.4.31 S-methyl-5'-thioadenosine deaminase S-methyl-5'-thioadenosine amidohydrolase
3.5.4.4 adenosine deaminase adenosine aminohydrolase
3.6.1.66 XTP/dITP diphosphatase XTP/dITP diphosphohydrolase (diphosphate-forming)


Proteins

Protein ID name full name