Nuclear events stimulated by ALK signaling in cancer

Ducray SP, Natarajan K, Garland GD, Turner SD, Egger G. The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis. Cancers (Basel). 2019 Jul 30;11(8). PMID: 31366041; PMCID: PMC6721376.; Della Corte CM, Viscardi G, Di Liello R, Fasano M, Martinelli E, Troiani T, Ciardiello F, Morgillo F. Role and targeting of anaplastic lymphoma kinase in cancer. Molecular Cancer. 2018 Feb 19;17(1):30. doi: 10.1186/s12943-018-0776-2.; Hallberg B, Palmer RH. The role of the ALK receptor in cancer biology. Ann Oncol. 2016 Sep;27 Suppl 3():iii4–iii15. doi: 10.1093/annonc/mdw301. PMID: 27573755.; Hallberg B, Palmer RH. Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Nat Rev Cancer. 2013 Oct;13(10):685–700. doi: 10.1038/nrc3580. PMID: 24060861.; Roskoski R. Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition. Pharmacol Res. 2013 Feb;68(1):68–94. doi: 10.1016/j.phrs.2012.11.007. PMID: 23201355.; Chiarle R, Voena C, Ambrogio C, Piva R, Inghirami G. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008 Jan;8(1):11–23. doi: 10.1038/nrc2291. PMID: 18097461.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.5.1.-
2.1.1.37 DNA (cytosine-5-)-methyltransferase S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.3.2.32 cullin-RING-type E3 NEDD8 transferase [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.4.21.79 granzyme B
3.5.1.98 histone deacetylase histone amidohydrolase
3.6.4.13 RNA helicase


Proteins

Protein ID name full name