Signaling by Rho GTPases, Miro GTPases and RHOBTB3

Peters DT, Kay L, Eswaran J, Lakey JH, Soundararajan M. Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism. Int J Mol Sci. 2018 Dec 02;19(12). PMID: 30513825; PMCID: PMC6321465.; Olson MF. Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors. Small GTPases. 2016 Aug 22;9(3):203–15. doi: 10.1080/21541248.2016.1218407.; Hodge RG, Ridley AJ. Regulating Rho GTPases and their regulators. Nature Reviews Molecular Cell Biology. 2016 Jun 15;17(8):496–510. doi: 10.1038/nrm.2016.67.; Ji W, Rivero F. Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis. Cells. 2016 Jun 14;5(2). PMID: 27314390; PMCID: PMC4931677.; Birsa N, Norkett R, Higgs N, Lopez-Domenech G, Kittler JT. Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins. Biochem Soc Trans. 2013 Dec;41(6):1525–31. doi: 10.1042/bst20130234. PMID: 24256248.; Tetlow AL, Tamanoi F. The Ras superfamily G-proteins. Enzymes. 2013;33 Pt A():1–14. doi: 10.1016/b978-0-12-416749-0.00001-4. PMID: 25033798.; Espinosa EJ, Calero M, Sridevi K, Pfeffer SR. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. Cell. 2009 May 29;137(5):938–48. PMID: 19490898; PMCID: PMC2801561.; Berthold J, Schenkova K, Rivero F. Rho GTPases of the RhoBTB subfamily and tumorigenesis. Acta Pharmacol Sin. 2008 Mar;29(3):285–95. doi: 10.1111/j.1745-7254.2008.00773.x. PMID: 18298893.; Boureux A, Vignal E, Faure S, Fort P. Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol. 2007 Jan;24(1):203–16. PMID: 17035353; PMCID: PMC2665304.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Superoxide

Formula: O2 (31.98983)

CAS ID: 11062-77-4

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.53 [myosin-light-chain] phosphatase [myosin-light-chain]-phosphate phosphohydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name