MITF-M-dependent gene expression

Dilshat R, Fock V, Kenny C, Gerritsen I, Lasseur RMJ, Travnickova J, Eichhoff OM, Cerny P, Möller K, Sigurbjörnsdóttir S, Kirty K, Einarsdottir BÓ, Cheng PF, Levesque M, Cornell RA, Patton EE, Larue L, de Tayrac M, Magnúsdóttir E, Ögmundsdóttir MH, Steingrimsson E. MITF reprograms the extracellular matrix and focal adhesion in melanoma. Elife. 2021 Jan 13;10(). PMID: 33438577; PMCID: PMC7857731.; Rambow F, Marine JC, Goding CR. Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities. Genes Dev. 2019 Oct 01;33(19-20):1295–318. PMID: 31575676; PMCID: PMC6771388.; Goding CR, Arnheiter H. MITF-the first 25 years. Genes Dev. 2019 Aug 01;33(15-16):983–1007. PMID: 31123060; PMCID: PMC6672050.; Hejna M, Moon WM, Cheng J, Kawakami A, Fisher DE, Song JS. Local genomic features predict the distinct and overlapping binding patterns of the bHLH-Zip family oncoproteins MITF and MYC-MAX. Pigment Cell Melanoma Res. 2019 Jul;32(4):500–9. PMID: 30548162; PMCID: PMC6555698.; Mort RL, Jackson IJ, Patton EE. The melanocyte lineage in development and disease. Development. 2015 Feb 15;142(4):620–32. PMID: 25670789; PMCID: PMC4325379.; Webster DE, Barajas B, Bussat RT, Yan KJ, Neela PH, Flockhart RJ, Kovalski J, Zehnder A, Khavari PA. Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition. Genome Res. 2014 May;24(5):751–60. PMID: 24443471; PMCID: PMC4009605.; Strub T, Giuliano S, Ye T, Bonet C, Keime C, Kobi D, Le Gras S, Cormont M, Ballotti R, Bertolotto C, Davidson I. Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011 May 19;30(20):2319–32. doi: 10.1038/onc.2010.612. PMID: 21258399.; Cheli Y, Ohanna M, Ballotti R, Bertolotto C. Fifteen-year quest for microphthalmia-associated transcription factor target genes. Pigment Cell Melanoma Res. 2010 Feb;23(1):27–40. doi: 10.1111/j.1755-148x.2009.00653.x. PMID: 19995375.; White RM, Zon LI. Melanocytes in development, regeneration, and cancer. Cell Stem Cell. 2008 Sep 11;3(3):242–52. doi: 10.1016/j.stem.2008.08.005. PMID: 18786412.; Bräuer AU, Savaskan NE, Kühn H, Prehn S, Ninnemann O, Nitsch R. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Nat Neurosci. 2003 Jun;6(6):572–8. doi: 10.1038/nn1052. PMID: 12730698.; Aksan I, Goding CR. Targeting the Microphthalmia Basic Helix-Loop-Helix–Leucine Zipper Transcription Factor to a Subset of E-Box Elements In Vitro and In Vivo. Molecular and Cellular Biology. 1998 Dec 01;18(12):6930–8. doi: 10.1128/mcb.18.12.6930.; Bentley NJ, Eisen T, Goding CR. Melanocyte-Specific Expression of the Human Tyrosinase Promoter: Activation by the Microphthalmia Gene Product and Role of the Initiator. Molecular and Cellular Biology. 1994 Dec 01;14(12):7996–8006. doi: 10.1128/mcb.14.12.7996-8006.1994.; Yavuzer U, Goding CR. Melanocyte-Specific Gene Expression: Role of Repression and Identification of a Melanocyte-Specific Factor, MSF. Molecular and Cellular Biology. 1994 May 01;14(5):3494–503. doi: 10.1128/mcb.14.5.3494-3503.1994.; Fisher F, Crouch DH, Jayaraman PS, Clark W, Gillespie DA, Goding CR. Transcription activation by Myc and Max: flanking sequences target activation to a subset of CACGTG motifs in vivo. The EMBO Journal. 1993 Dec;12(13):5075–82. doi: 10.1002/j.1460-2075.1993.tb06201.x.; Solomon DL, Amati B, Land H. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 1993 Nov 25;21(23):5372–6. PMID: 8265351; PMCID: PMC310573.; Lowings P, Yavuzer U, Goding CR. Positive and Negative Elements Regulate a Melanocyte-Specific Promoter. Molecular and Cellular Biology. 1992 Aug 01;12(8):3653–62. doi: 10.1128/mcb.12.8.3653-3662.1992.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name