Aspirin ADME

Dressman JB, Nair A, Abrahamsson B, Barends DM, Groot DW, Kopp S, Langguth P, Polli JE, Shah VP, Zimmer M. Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Acetylsalicylic Acid. Journal of Pharmaceutical Sciences. 2012 Aug;101(8):2653–67. doi: 10.1002/jps.23212.; Yee S. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man--fact or myth. Pharm Res. 1997 Jun;14(6):763–6. doi: 10.1023/a:1012102522787. PMID: 9210194.; Artursson P, Karlsson J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochemical and Biophysical Research Communications. 1991 Mar;175(3):880–5. doi: 10.1016/0006-291x(91)91647-u.; Needs CJ, Brooks PM. Clinical pharmacokinetics of the salicylates. Clin Pharmacokinet. 1985 Mar;10(2):164–77. doi: 10.2165/00003088-198510020-00004. PMID: 3888490.; Rainsford KD. The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs. Agents Actions. 1977 Dec;7(5-6):573–7. doi: 10.1007/bf02111132. PMID: 602882.; Rainsford KD. The biochemical pathology of aspirin-induced gastric damage. Agents Actions. 1975 Oct;5(4):326–44. doi: 10.1007/bf02205240. PMID: 1980.; Flower RJ. Drugs Which Inhibit Prostaglandin Biosynthesis. Pharmacological Reviews. 1974 Mar;26(1):33–67. doi: 10.1016/s0031-6997(25)06634-7.; Mills DG, Philp RB, Hirst M. The effects of some salicylate analogues on human blood platelets. 1. Structure activity relationships and the inhibition of platelet aggregation. Life Sci. 1974 Feb 16;14(4):659–72. doi: 10.1016/0024-3205(74)90449-4. PMID: 4823623.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Gentisuric acid

Formula: C9H9NO5 (211.04807040000003)

CAS ID: 25351-24-0

Salicylates

Formula: C7H5O3 (137.023868)

CAS ID: 63-36-5

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

2,5-dihydroxybenzoate

Formula: C7H5O4 (153.018783)

CAS ID: 490-80-2

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.1.7 acetylcholinesterase acetylcholine acetylhydrolase


Proteins

Protein ID name full name