superpathway of purine nucleotides de novo biosynthesis I
Zrenner R, Stitt M, Sonnewald U, Boldt R. Pyrimidine and purine biosynthesis and degradation in plants. Annu Rev Plant Biol. 2006;57():805–36. doi: 10.1146/annurev.arplant.57.032905.105421. PMID: 16669783.; He B, Smith JM, Zalkin H. Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR. J Bacteriol. 1992 Jan;174(1):130–6. doi: 10.1128/jb.174.1.130-136.1992.
Metabolites
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
Formula: C9H13N4O8P (336.0470988)
CAS ID:
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.205 | IMP dehydrogenase | IMP:NAD+ oxidoreductase | |
| 1.17.4.1 | ribonucleoside-diphosphate reductase | 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase | |
| 2.1.2.2 | phosphoribosylglycinamide formyltransferase 1 | 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase | |
| 2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase | 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase | |
| 2.4.2.14 | amidophosphoribosyltransferase | 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) | |
| 2.7.13.3 | histidine kinase | ATP:protein-L-histidine N-phosphotransferase | |
| 2.7.4.3 | adenylate kinase | ATP:AMP phosphotransferase | |
| 2.7.4.6 | nucleoside-diphosphate kinase | ATP:nucleoside-diphosphate phosphotransferase | |
| 2.7.4.8 | guanylate kinase | ATP:(d)GMP phosphotransferase | |
| 3.5.4.10 | IMP cyclohydrolase | IMP 1,2-hydrolase (decyclizing) | |
| 4.1.1.21 | phosphoribosylaminoimidazole carboxylase | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming] | |
| 4.3.2.2 | adenylosuccinate lyase | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) | |
| 6.3.2.6 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming) | |
| 6.3.3.1 | phosphoribosylformylglycinamidine cyclo-ligase | 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) | |
| 6.3.4.13 | phosphoribosylamine-glycine ligase | 5-phospho-D-ribosylamine:glycine ligase (ADP-forming) | |
| 6.3.4.4 | adenylosuccinate synthase | IMP:L-aspartate ligase (GDP-forming) | |
| 6.3.5.2 | GMP synthase (glutamine-hydrolysing) | xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) | |
| 6.3.5.3 | phosphoribosylformylglycinamidine synthase | N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P04046 | ADE4 | Amidophosphoribosyltransferase |
| P04161 | ADE8 | Phosphoribosylglycinamide formyltransferase |
| P07170 | ADK1 | Adenylate kinase |
| P07244 | ADE57 | Bifunctional purine biosynthetic protein ADE5,7 |
| P09938 | RNR2 | Ribonucleoside-diphosphate reductase small chain 1 |
| P15454 | GUK1 | Guanylate kinase |
| P21264 | ADE2 | Phosphoribosylaminoimidazole carboxylase |
| P21524 | RNR1 | Ribonucleoside-diphosphate reductase large chain 1 |
| P27616 | ADE1 | Phosphoribosylaminoimidazole-succinocarboxamide synthase |
| P36010 | YNK1 | Nucleoside diphosphate kinase |
| P38009 | ADE17 | Bifunctional purine biosynthesis protein ADE17 |
| P38625 | GUA1 | GMP synthase [glutamine-hydrolyzing] |
| P38972 | ADE6 | Phosphoribosylformylglycinamidine synthase |
| P49723 | RNR4 | Ribonucleoside-diphosphate reductase small chain 2 |
| P54113 | ADE16 | Bifunctional purine biosynthesis protein ADE16 |
| P80210 | ADE12 | Adenylosuccinate synthetase |
| Q05911 | ADE13 | Adenylosuccinate lyase |