Maturation of TCA enzymes and regulation of TCA cycle

Arnold PK, Finley LWS. Regulation and function of the mammalian tricarboxylic acid cycle. Journal of Biological Chemistry. 2023 Feb;299(2):102838. doi: 10.1016/j.jbc.2022.102838.

Metabolites

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

butenedioate

Formula: C4H2O4 (113.99530920000001)

CAS ID: 17013-01-3

4-hydroxybutyrate

Formula: C4H7O3 (103.0395172)

CAS ID: 1320-61-2

2''-O-acetyl-ADP-D-ribose(2-)

Formula: C17H23N5O15P2 (599.0665868000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.1.5.-
1.1.1.42 isocitrate dehydrogenase (NADP+) isocitrate:NADP+ oxidoreductase (decarboxylating)
1.16.3.1 ferroxidase Fe(II):oxygen oxidoreductase
1.3.5.1 succinate dehydrogenase succinate:quinone oxidoreductase
2.3.1.9 acetyl-CoA C-acetyltransferase acetyl-CoA:acetyl-CoA C-acetyltransferase
2.8.1.7 cysteine desulfurase L-cysteine:acceptor sulfurtransferase
4.2.1.3 aconitate hydratase citrate(isocitrate) hydro-lyase (cis-aconitate-forming)


Proteins

Protein ID name full name