superpathway of 5-aminoimidazole ribonucleotide biosynthesis

Nygaard P, Smith JM. Evidence for a novel glycinamide ribonucleotide transformylase in Escherichia coli. J Bacteriol. 1993 Jun;175(11):3591–7. doi: 10.1128/jb.175.11.3591-3597.1993.

Metabolites

Cobalt ion

Formula: Co (58.933198)

CAS ID: 22541-53-3

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

iodoacetamide

Formula: C2H4INO (184.9337644)

CAS ID: 144-48-9

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

2-Amino-5-chloro-4-oxopentanoic acid

Formula: C5H8ClNO3 (165.0192688)

CAS ID: 15148-06-8



Enzyme

EC Number name full name note
2.1.2.2 phosphoribosylglycinamide formyltransferase 1 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase
2.4.2.14 amidophosphoribosyltransferase 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
6.3.1.21 phosphoribosylglycinamide formyltransferase 2 formate:N1-(5-phospho-beta-D-ribosyl)glycinamide ligase (ADP-forming)
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
6.3.4.13 phosphoribosylamine-glycine ligase 5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
6.3.5.3 phosphoribosylformylglycinamidine synthase N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)


Proteins

Protein ID name full name
P08178 purM Phosphoribosylformylglycinamidine cyclo-ligase
P08179 purN Phosphoribosylglycinamide formyltransferase
P0AG16 purF Amidophosphoribosyltransferase
P15254 purL Phosphoribosylformylglycinamidine synthase
P15640 purD Phosphoribosylamine--glycine ligase
P33221 purT Formate-dependent phosphoribosylglycinamide formyltransferase