Transport of RCbl within the body

Banerjee R, Gouda H, Pillay S. Redox-Linked Coordination Chemistry Directs Vitamin B12 Trafficking. Acc. Chem. Res. 2021 Apr 02;54(8):2003–13. doi: 10.1021/acs.accounts.1c00083.; Nielsen MJ, Rasmussen MR, Andersen CB, Nexø E, Moestrup SK. Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway. Nat Rev Gastroenterol Hepatol. 2012 May 01;9(6):345–54. doi: 10.1038/nrgastro.2012.76. PMID: 22547309.; Quadros EV. Advances in the understanding of cobalamin assimilation and metabolism. Br J Haematol. 2009 Dec 17;148(2):195–204. doi: 10.1111/j.1365-2141.2009.07937.x.; Chu RC, Begley JA, Colligan PD, Hall CA. The methylcobalamin metabolism of cultured human fibroblasts. Metabolism. 1993 Mar;42(3):315–9. doi: 10.1016/0026-0495(93)90080-8. PMID: 8487649.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
7.6.2.2 ABC-type xenobiotic transporter ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
7.6.2.3 ABC-type glutathione-S-conjugate transporter ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]
7.6.2.8 ABC-type vitamin B12 transporter ATP phosphohydrolase (ABC-type, vitamin B12-importing)


Proteins

Protein ID name full name